Fig. 1.

Eicosanoids and the associated enzymes are comprised in EVs. Cells produce different types of EVs, such as exosomes and microvesicles. Exosomes are stored in multivesicular bodies (MVBs) and released on cell activation, whereas microvesicles are generated by plasma membrane budding and shedding. Graphic representation of the metabolism of AA into eicosanoids. AA, arachidonic acid; COX-1, cyclooxygenase-1; COX-2, cyclooxygenase-2; TX, thromboxane; 12-LO, 12-lipoxygenase; 5-LO, 5-lipoxygenase; LT, leukotriene; PG, prostaglandin; HETE ; hydroxyeicosatetraenoic acid.