Fig. 8.

Effect of Myr-[R]hE18A-NH₂ on the cholesterol profiles at different times postadministration in a cynomolgus monkey. Lipoprotein profiles for a monkey receiving Myr-[R]hE18A-NH₂ at a dose of 7.4 mg/kg at time points up to 1 day (A) and 7 days (B) after peptide administration. Plasma samples (100 uL) were injected onto a Superose column. PBS (0.4 ml/min) was used to elute the samples. Cholesterol reagent (0.2 ml/min) was then mixed with the eluent, followed by heating to 57°C and measurement of UV absorbance at 540 nm.