TABLE 2.
Time-dependent changes in plasma lipoproteins in cynomolgus macaques treated with 7.4 mg/kg Myr-[R]hE18A-NH2.
Time | TC | LDL | HDL-C | Triglycerides |
mg/dl | ||||
Predose | 296 ± 38 | 223 ± 47 | 60 ± 14 | 68 ± 14 |
1 h | 190 ± 42 | 135 ± 43 | 42 ± 8 | 67 ± 16 |
8 h | 154 ± 40* | 105 ± 34 | 35 ± 10 | 70 ± 14 |
1 day | 108 ± 22* | 58 ± 22* | 33 ± 9 | 83 ± 19 |
3 days | 142 ± 14* | 87 ± 10* | 41 ± 6 | 72 ± 21 |
7 days | 271 ± 40 | 205 ± 43 | 54 ± 8 | 69 ± 5 |
P < 0.05 versus predose level.