Table 3.
Performance of serum biomarkers in a combined validation set.
| Comparison | Marker | p | AUC (95% CI) | Sensitivity at 95% Specificity | Specificity at 95% Sensitivity |
|---|---|---|---|---|---|
| PDAC vs. Healthy control | miR-196b | 0.0051 | 0.8938 (0.7395 to 1.048) |
80% | 50% |
| TIMP1 | <0.0001 | 0.9617 (0.9125 to 1.011) |
93.6% | 70% | |
| LCN2 | 0.0007 | 0.9500 (0.8477 to 1.052) |
50% | 90% | |
| RNU2-1f | <0.0001 | 1.0000 (1.0000 to 1.000) |
100% | 100% | |
| Glypican-1 | 0.2700 | 0.6106
(0.4332 to 0.7881) |
31% | 0% | |
| FPC vs. Healthy control | miR-196b | 0.0006 | 0.9716 (0.9052 to 1.038) |
90% | 70% |
| TIMP1 | 0.0001 | 0.9600 (0.8871 to 1.033) |
86% | 50% | |
| LCN2 | <0.0001 | 0.9786 (0.9289 to 1.028) |
78% | 90% | |
| RNU2-1f | 0.0002 | 1.0000
(1.0000 to 1.000) |
100% | 100% | |
| Relevant lesions vs. Healthy controls | miR-196b | 0.0011 | 0.9722 (0.9034 to 1.041) |
88.9% | 75% |
| TIMP1 | 0.0048 | 0.9600 (0.8633 to 1.057) |
80% | 80% | |
| LCN2 | 0.0024 | 0.9667 (0.8857 to 1.048) |
67% | 90% | |
| RNU2-1f | 0.8073 | 0.537 (0.2468 to 0.8247) |
14.3% | 10% | |
| Glypican-1 | 0.9717 | 0.5046
(0.2438 to 0.7655) |
11.1% | 16.7% | |
| Significant lesions vs. Healthy controls | miR-196b | 0.0066 | 1.0000 (1.0000 to 1.000) | 100% | 100% |
| High grade only | TIMP1 | 0.0047 | 1.0000 (1.0000 to 1.000) |
100% | 100% |
| LCN2 | 0.0047 | 1.0000 (1.0000 to 1.000) |
100% | 100% | |
| RNU2-1f | 0.3580 | 0.6625
(0.3679 to 0.9571) |
25% | 50% | |
| PDAC vs. chronic pancreatitis | miR-196b | 0.0539 | 0.7550 (0.5074 to 1.003) |
60% | 70% |
| TIMP1 | 0.0126 | 0.8300 (0.6132 to 1.047) |
10% | 80% | |
| LCN2 | 0.0015 | 0.920 (0.7673 to 1.073) |
20% | 90% | |
| RNU2-1f | <0.0001 | 1.0000 (1.0000 to 1.000) |
100% | 100% | |
| Glypican-1 | 0.9615 | 0.5052
(0.2850 to 0.7213) |
10.3% | 0% | |
| FPC vs. chronic pancreatitis | miR-196b | 0.0411 | 0.7636 (0.5475 to 0.979) |
55% | 0% |
| TIMP1 | 0.0078 | 0.8200 (0.6232 to 1.017) |
21% | 60% | |
| LCN2 | 0.0004 | 0.9286 (0.8029 to 1.054) |
36% | 80% | |
| RNU2-1f | <0.0001 | 1.0000
(1.0000 to 1.000) |
100% | 100% |
PDAC, pancreatic ductal adenocarcinoma, FPC, familial pancreatic cancer, AUC, area under curve, CI, confidence interval.