. 2018 Oct 12;10(10):381. doi: 10.3390/cancers10100381

Table 1.

Single Nucleotide Polymorphisms (SNPs) within miRNA-encoding genes and their association with Esophageal Cancer (EC) risk and outcome.

Location	SNP	Population	Type of Study	Sample Size	Relevant Genotype	Outcome	References
Pri-miR-124-1	rs531564	Kazach	Case controls	239 cases/227 controls	CG+GG	↓ ESCC risk	Wu et al. (2018) [35]
Pri-miR-124-1	rs531564	Canadian	Cohort	368 cases	G allele	↑ EAC OS	Faluyi et al. (2017) [36]
Pre-miR-423	rs6505162	Iranian	Case control	200 cases/300 controls	AA	↓ EC risk	Nariman-Saleh-Fam et al. (2016) [14]
Pre-miR-196a2	rs11614913	Chinese	Case control	1400 cases/2185 controls	CC	↑ ESCC risk	Shen et al. (2016) [37]
Pre-miR-499	rs3746444	Chinese	Case control	1400 cases/2185 controls	C allele	↑ ESCC risk	Shen et al. (2016) [37]
Pre-miR-4467 Pre-miR-3117	rs12534337 rs7526812	Mixed ethnicity	Case control	2515 EA cases 3295 BE cases 3207 controls	A allele C allele	↑ BE and ↑ EAC risk	Buas et al. (2015) [8]
Pri-miR-124-1	rs531564	Chinese	Meta analysis	1738 cases/1961 controls	GG	↓ ESCC risk	Li et al. (2015) [38]
Pre-miR-219-1	rs107822	Kazach	Case control	248 cases/300 controls	AA/A allele	↓ ESCC risk	Song et al. (2015) [39]
Pre-miR-219-1	rs213210	Kazach	Case control	248 cases/300 controls	T allele	↓ ESCC risk	Song et al. (2015) [39]
Pre-miR-100	rs1834306	Kazach	Case control	248 cases/300 controls	CC/C allele	↓ ESCC risk	Zhu et al. (2015) [40]
Pre-miR-499b	rs10061133	Chinese	Case control	773 cases/882 controls	GG	↓ ESCC risk	Zhang et al. (2015) [41]
Pre-miR-4293	rs12220909	Chinese	Case control	773 cases/882 controls	C allele	↓ ESCC risk	Zhang et al. (2015) [41]
Pre-miR-196a-2	rs11614913	Chinese	Case control	381 cases/426 controls	TT	↓ ESCC risk	Qu et al. (2014) [42]
Pre-miR-499	rs3746444	Mixed ethnicity	Meta analysis	12799 cases/14507 controls	TC+CC	↑ EC risk in the asian population	Chen et al. (2014) [43]
Pri-miR-34b/c	rs4938723	Mixed ethnicity	Meta analysis	7753 cases/8014 controls	CC	↓ ESCC risk in the asian population	Li et al. (2014) [44]
Pre-miR-608	rs4919510	Taiwan	Cohort	504 cases	GC	↑ OS and ↑ PFS in ESCC	Yang et al. (2014) [45]
Pre-miR-146a	rs2910164	Chinese	Cohort	378 cases	CG+GG	↑ risk of severe hematological toxicity in ESCC	Wu et al. (2014) [46]
Pre-miR-196a2	rs11614913				TT	↓ OS ESCC
Pre-miR-125a	rs12976445				TT	↓ OS ESCC
Pre-miR-196a-2	rs11614913	Chinese	Case control	597 cases/597 controls	CT+TT	↑ ESCC risk	Wang et al. (2014) [47]
Pre-miR-146a	rs2910164	Mixed ethnicity	Meta analysis	790 cases/814 controls	GC+GG	↑ EC risk in the asian population	Xu et al. (2014) [48]
Pre-miR-423	rs6505162	Chinese	Case control	629 cases/686 controls	AA	↑ ESCC risk	Yin et al. (2013) [49]
Pre-miR-423	rs6505162	Black ethnicity	Case control	368 cases/583 controls	C allele	↑ ESCC risk	Wang et al. (2013) [50]
5 ′ -UTR miR-26a-1	rs7372209	Mixed ethnicity	Case control	197 cases/420 controls	T allele	↑ ESCC risk	Wang et al. (2013) [50]
Pre-miR-196a-2	rs11614913	Chinese	Case control	380 cases/380 controls	CC	↓ ESCC risk in women	Wei et al. (2013) [51]
Pre-miR-196a-2	rs11614913	Mixed ethnicity	Meta analysis	4947 cases and 5642 controls	C allele	↑ EC risk	Wang et al. (2013) [52]
Pre-miR-196a2	rs11614913	Indian	Meta analysis	289 cases/309 controls	T allele	↓ OS in ESCC	Umar et al. (2013) [53]
Pre-miR-146a	rs2910164				C allele
Pre-miR-499	rs3746444				C allele
Pre-miR-423	rs6505162				A allele
Pre-miR-146a	rs2910164	Mixed ethnicity	Meta analysis	772 cases/779 controls	C allele	↓ EC risk in the asian population	He et al. (2012) [54]
Pre-miR-423	rs6505162	Caucasian	Case control	346 cases/346 controls	AC+AA	↓ EC risk	Ye et al. (2008) [55]

EC: Esophageal Cancer; EAC: Esophageal Adenocarcinoma; ESCC: Esophageal squamous cell carcinoma; BE: Barrett Esophagus; OS: overall survival; PFS: progression-free survival; ↑: high; ↓: low.