Table 1.
Catalog of Somatic Mutations in Cancer (COSMIC) Database Interrogation for Unfolded Protein Response (UPR) Mutants.
| Inositol-requiring enzyme (IRE1) | |
| Luminal domain | p.P75Q, p.A371A, p.H386fs*8 |
| Transmembrane domain | p.L454L |
| Cytoplasmic domain | p.Q495_L496insQ |
| Kinase domain | p.G703D, p.L714L, p.V767A, p.R806C, p.A823V, p.F937F |
| X-box binding protein 1 (XBP1) | |
| bZIP/nuclear localization signal | p.R81fs*16, p.R90P |
| bZIP/leucine zipper | p.E108delE, p.E121D |
| Translational pausing of own mRNA | p.L236fs*16, p.L238fs*13 |
| Other regions | p.P8P, p.P37A, p.Q43E, p.E97delE, p.S187fs*6, p.S190fs*1, p.P213fs*45, p.L232fs*22 |
| PKR-like ER Kinase (PERK) | |
| Luminal domain | p.R114I, p.S385R |
| Cytoplasmic domain | p.T537T, p.R588P, p.D1081fs*31, p.L1088L, p.S1098L |
| Cytoplasmic/kinase domain | p.S686F, p.C788C, p.R797T, p.R1027G, p.E1050D |
| Activating transcription factor 6 (ATF6) | |
| Cytoplasmic/transcription activation | p.E25Q |
| Cytoplasmic domain | p.Q237 * |
| Cytoplasmic/basic motif | p.R309K, p.K327N, |
| Cytoplasmic/bZIP | p.E365Q |
| Luminal domain | p.A450fs*7, p.C467fs*1, p.L477F, p.R484Q, p.S592S, p.R624S, p.S631L |
| Glucose-regulated protein 78 kDa (GRP78) | |
| Signal peptide | p.L13L |
| Nucleotide-binding domain | p.I132T, p.K138N, p.T166T, p.E243K |
| ATP-binding | p.A295fs*28 |
| Other regions | p.E308Q, p.E514Q, p.E603E |