TABLE 1.
The fold change and adjusted P values from the SS (+glc +AA) versus SS (−glc +AA) DGE comparison for top genes changing toward or against progression
| Gene ID | Gene producta | LogFC (LS vs PF)b | Adj. P valuec | LogFC (SS+glc vs SS−glc)d | Adj. P valuec |
|---|---|---|---|---|---|
| Toward progression | |||||
| Tb927.6.510 | GPEET | 6.22 | 0.00E+00 | 0.94 | 4.70E−14 |
| Tb927.10.15410 | gMDH | 5.23 | 0.00E+00 | 0.57 | 3.00E−27 |
| Tb927.10.10260 | EP1 | 6.41 | 8.53E−318 | 0.86 | 1.20E−47 |
| Tb927.11.6280 | PPDK | 4.25 | 0.00E+00 | 0.3 | 1.30E−06 |
| Tb927.10.2560 | mMDH | 3.51 | 0.00E+00 | 0.3 | 1.70E−07 |
| Tb927.6.520 | EP3-2 | 5.76 | 0.00E+00 | 0.46 | 1.40E−19 |
| Tb927.7.5940 | PAD2 | 2.14 | 9.7596E−103 | 1.2 | 1.50E−76 |
| Tb927.3.4500 | FHc | 3.70 | 2.89E−310 | 0.28 | 2.80E−05 |
| Tb927.7.210 | PRODH | 2.65 | 5.36E−316 | 0.57 | 9.70E−24 |
| Tb927.9.5900 | GDH | 2.86 | 5.3834E−138 | 1.2 | 1.30E−82 |
| Against progression | |||||
| Tb11.1690 | VSG | −22.12 | 0.00E+00 | 0.01 | 9.20E−01 |
| Tb927.10.5620 | ALD | −1.51 | 1.69E−184 | −0.41 | 3.40E−17 |
| Tb927.3.3270 | PFK | −2.09 | 6.80E−129 | −0.18 | 2.10E−02 |
| Tb927.10.14140 | PYK1 | −2.76 | 0.00E+00 | −0.5 | 3.40E−18 |
| Tb927.10.8230 | PDI2 | −2.00 | 2.3277E−174 | −1.1 | 2.20E−97 |
| Tb927.10.2890 | ENO | 0.06 | 3.42E−01 | −0.24 | 2.10E−05 |
| Tb927.1.3830 | PGI | −1.49 | 8.29E−93 | −0.29 | 2.50E−06 |
| Tb927.1.700 | PGKC | −3.21 | 6.71E−310 | −0.43 | 2.50E−08 |
| Tb927.10.3990 | DHH1 | −0.55 | 8.16E−08 | −0.33 | 3.60E−07 |
| Tb927.10.6880 | GAP | −0.65 | 1.01E−25 | −0.75 | 6.50E−47 |
GPEET, GPEET procyclin; gMDH, glycosomal malate dehydrogenase; EP1, EP1 procyclin; PPDK, pyruvate phosphate dikinase; mMDH, mitochondrial malate dehydrogenase; EP3-2, EP3-2 procyclin; PAD2, protein associated with differentiation 2; FHc, cytosolic fumarate hydratase; PRODH, proline dehydrogenase; GDH, glutamate dehydrogenase; VSG, variant surface glycoprotein; ALD, fructose-bisphosphate aldolase; PFK, ATP-dependent 6-phosphofructokinase; PYK1, pyruvate kinase 1; PDI2, protein disulfide isomerase 2; ENO, enolase; PGI, glucose-6-phosphate isomerase; PGKC, phosphoglycerate kinase C; DHH1, DExD/H-box ATP-dependent RNA helicase.
LogFC (LS vs PF), the log2 fold change value of transcripts from LS incubated in glucose-rich media compared to that from PF very-low-glucose media.
Adjusted P value was calculated using the Benjamini-Hochberg method on P values generated by likelihood ratio.
LogFC (SS+glc vs SS−glc), the log2 fold change value of transcripts from SS incubated in very-low-glucose media compared to that from SS in glucose-rich media.