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. 2018 Jul 27;187(11):2346–2354. doi: 10.1093/aje/kwy155

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© The Author(s) 2018. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Horvath DNA methylation age (years) according to chronological age (years) among men (A) and women (B) in the UK Household Longitudinal Study (n = 1,093), 2011–2012. The solid line represents the line of best fit, and the dashed line is the y = x line. ΔAge (years) is the difference between DNA methylation age and chronological age (i.e., the vertical distance from a dot to the y = x line). If mean Δage were constant with age, observations would be approximately symmetrical about the y = x line. Instead, Δage decreases with chronological age. UK, United Kingdom.