Table 1.

Association between clinicopatholog¡c tumor features of ccRCCs in training and validation sets of TCGA and DNA methylation subgroups

	Training dataset (450 K)				Validation dataset (27 K)
Variable	No-CIMP (n = 53)	Low-CIMP (n = 153)	C-CIMP (n = 65)	P	No-CIMP (n = 46)	Low-CIMP (n = 75)	C-CIMP (n = 39)	P
Age (years)	63	59	65	0.003	52	64	60.5 (37–85)	0.0002
Median (range)	(32–86)	(26–90)	(41–90)		(34–80)	(42–86)
Gender				0.001				0.24
Male	42	66	50		25	41	32
Female	11	87	15		14	34	14
Laterality				0.28				0.31
Right	27	88	30		19	43	20
Left	26	65	35		20	32	26
Histologic grade				<10e−5				<10e−5
G1	0	4	0		2	2	0
G2	10	89	15		26	38	9
G3	27	50	28		7	29	21
G4	16	9	21		0	6	16
Gx	0	1	1		3	0	0
Pathologic TNM stage				<10e−5				<1.2e−5
I	12	103	11		30	37	12
II	6	13	5		4	11	7
III	21	25	21		5	20	12
IV	14	12	28		0	7	15
Pathologic T				<0.0001				0.0002
T1	14	103	12		30	37	13
T2	8	16	9		4	11	9
T3	29	33	39		5	27	22
T4	2	1	5		0	0	2
Pathologic N				0.06				0.005
N0	26	72	23		16	47	24
N1	4	2	3		0	0	5
Pathologic M				<0.0001				<0.0001
M0	40	141	38		39	67	31
M1	13	12	27		0	8	15