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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: J Immunol Methods. 2014 Apr 24;410:88–99. doi: 10.1016/j.jim.2014.04.007

Table I.

Summary of mouse models for S. aureus infection

Disease model Infection route Infectious dose
(CFUs)		 Phenotype References
Skin infection Subcutaneous 1×107 – 1×109 Dermonecrosis caused by secreted toxins (46, 59)
Metastatic abscess formation Intravenous 1×106 – 1×107 Abscess formation in most internal organs (3)
Sepsis Intravenous 5×107 – 5×108 Acute lethal disease within 48 hours of infection; formation of multiple lesions in heart (119, 133)
Peritonitis Intraperitoenal 5×108 (LD50)
6×109 (LD90)		 Acute lethal disease within 12 hours of infection; formation of abscess lesions on peritoneal surfaces (43)
Pneumonia Intranasal 2-4×108 Acute lethal disease within 72 hours of infection; infiltration of inflammatory cells into alveolar air space (45)