Table 5.
Ratios for use in routine clinical practice
| To: From: | Mpo | Msc | Miv | Msu | HMpo | HMsc | HMiv | OXpo | OXsc | OXiv | Ftd | Fsc | Fiv |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mpo | 2:1* | 1:0.31 | 1:1 | 5:1 (range 1.33–16.67:1) | 1.3 to 1.5:1a | 70:1 to 78:1a | 85.4:1 (range 65– 112.5) | 100:1* | |||||
| Msc | 1:2* | 1:2.4 | 5:1 (range 1.33–16.67:1) | 1.2:1 (±0.4) | 66:1 | ||||||||
| Miv | 1:3* | 28:1 (lower dose Miv) to 48:1 (higher dose Miv) | |||||||||||
| Msu | 1:1 | 2.4:1 | |||||||||||
| HMpo | 1:3.7 (range 1.35–5) | 1:4.13 | |||||||||||
| HMsc | 1:3.7 (range 1.35–5) | 0.5(±0.4):1 | |||||||||||
| HMiv | 1:11 | 1:2.5 (range 2.14–2.75) | 1:8.06 | ||||||||||
| OXpo | 1:1.5 | 4.13:1 | 1:0.70 | ||||||||||
| OXsc | 1:1.2 (±0.4) | 1:0.5 (±0.4) | |||||||||||
| OXiv | 0.70:1 | ||||||||||||
| Ftd | 1:70 to 1:78a | 1:1 | |||||||||||
| Fsc | 1:85.4 (range 65– 112.5) | 1:66 | |||||||||||
| Fiv | 1:100* | 1:1 |
Notes: Data are expressed in accordance with published results; that is why both ranges and standard errors are presented in this table, depending on the source.
*
(Shaded box) pharmaceutical industry data.
a
When two or more published data are available, we present the range of results (ie, lowest and highest published ratios).
Abbreviations: F, fentanyl; HM, hydromorphone; iv, intravenous; M, morphine sulfate; NA, not available or not applicable; Msu, morphine; OX, oxycodone; po, oral; RCT, randomized controlled trial; sc, subcutaneous; td, transdermal.