Table 1.
Characteristic of patients at baseline
| Group | Swtich-to | Add-on | ETV | P-value |
|---|---|---|---|---|
|
| ||||
| N | 22 | 26 | 53 | |
| Age (years) | 35.2 (25–50) | 43.17 (27–60) | 45.6 (28–65) | <0.001 |
| Male, n, % | 21, 95 | 24, 92 | 37, 70 | 0.02 |
| BMI <24 | 55% (12/22) | 58% (15/26) | 58% (31/53) | NS |
| HBsAg (IU/mL) | 1,250 (±1738) | 1,219 (±1736) | 1,898 (±1317) | NS |
| HBV DNA undetectable | 22 | 26 | 53 | NS |
| ALT (IU/L) | 32.45 (±13.73) | 31.83 (±14.16) | 29.8 (±12.98) | NS |
| AST (IU/L) | 29.15 (±14.49) | 29.57 (±12.51) | 26.37 (±9.118) | NS |
| ALB (g/L) | 45.85 (±3.36) | 45 (±2.404) | 43.9 (±3.977) | NS |
| WBC (109/L) | 5.178 (±1.566) | 5.469 (±1.566) | 5.276 (±1.207) | NS |
| PLT (109/L) | 178.4 (±48.65) | 176.5 (±47.75) | 154.9 (±53.53) | NS |
| Liver stiffness (kPa) >9 | 36% (8/22) | 35% (9/26) | 38% (20/53) | NS |
Notes: Continuous data are expressed as the mean ± SD, age shown with the mean (range). Categorical data, male, BMI, liver stiffness, shows with number and proportion. Liver stiffness >9 kPa refers to sever liver fibrosis or cirrhosis.17
Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALB, albumin; BMI, body mass index; ETV, entecavir; HBsAg, hepatitis B surface antigen; HBV, hepatitis B virus; WBC, white blood cell; PLT, platelet; NS, non-significant.