Table 6.

Acute effect of compounds 11, 17, 25, 28 and 35 on blood glucose levels in STZ-diabetics mice.

Test samples	Blood glucose concentration(mM)
	Dose(per os) mg/kg of bw	0h	1.5h	3h	5h	7h	9h
Control (vehicle)	–	24.7 ± 5.8	22.7 ± 5.4	15.9 ± 4.9	15.4 ± 6.5	14.9 ± 7.1	15.8 ± 5.3
			(−8.23)	(−35.63)	(−37.79)	(−39.88)	(−35.97)
Glibenclamide	10	16.9 ± 4.3	7.2 ± 4.0*	6.9 ± 1.6	6.7 ± 2.5	6.5 ± 2.2	4.9 ± 2.5**
			(−55.28)	(−57.14)	(−55.90)	(−59.63)	(−70.81)
11	10	24.9 ± 4.1	20.6 ± 5.9	15.5 ± 8.5	12.8 ± 10.4	11.4 ± 8.2	11.9 ± 8.5
			(−17.27)	(−37.75)	(−48.59)	(−54.22)	(−52.21)
11	30	25.3 ± 6.3	20.0 ± 6.3	16.5 ± 6.4	11.3 ± 4.0	9.5 ± 3.9	8.1 ± 4.2
			(−20.95)	(−34.78)	(−55.41)	(−62.40)	(−68.14)
11	100	23.5 ± 5.4	18.3 ± 3.9	15.3 ± 3.9	11.1 ± 4.4	8.9 ± 2.8	8.2 ± 2.6
			(−21.88)	(−34.89)	(−52.76)	(−62.21)	(−65.27)
17	10	26.9 ± 3.8	24.5 ± 3.0	22.8 ± 2.3	16.6 ± 5.8	14.8 ± 8.0	14.7 ± 9.5
			(−8.92)	(−15.24)	(−38.29)	(−44.98)	(−45.35)
17	30	23.3 ± 3.2	17.9 ± 5.7	11.6 ± 4.8	8.3 ± 3.8	7.4 ± 6.7	6.9 ± 7.9*
			(−23.18)	(−50.22)	(−64.38)	(−68.24)	(−70.39)
17	100	23.4 ± 5.7	18.8 ± 6.0	12.5 ± 4.7	7.6 ± 3.8	6.9 ± 2.6	8.0 ± 2.3
			(−19.66)	(−46.58)	(−67.52)	(−70.51)	(−65.81)
25	10	19.7 ± 6.1	15.7 ± 6.6	14.9 ± 6.5	9.7 ± 3.4	6.9 ± 3.9	8.5 ± 2.2
			(−20.30)	(−24.37)	(−50.76)	(−64.97)	(−56.85)
25	30	24.8 ± 4.9	21.7 ± 3.9	15.8 ± 4.5	8.9 ± 6.3	9.0 ± 4.8	8.9 ± 3.8
			(−12.50)	(−36.23)	(−64.11)	(−63.71)	(−64.11)
25	100	23.0 ± 4.8	18.3 ± 3.5	17.2 ± 2.9	9.9 ± 2.7	8.1 ± 1.6	9.1 ± 2.3
			(−20.44)	(−25.36)	(−56.95)	(−64.78)	(−60.43)
28	10	15.3 ± 3.8	14.8 ± 5.8	11.4 ± 4.2	8.9 ± 2.6	6.4 ± 1.6	7.0 ± 2.4
			(−3.27)	(−25.49)	(−41.83)	(−58.17)	(−54.25)
28	30	18.2 ± 6.7	14.9 ± 6.6	13.5 ± 6.1	12.7 ± 6.7	10.3 ± 5.6	7.3 ± 4.5
			(−18.13)	(−25.82)	(−30.22)	(−43.41)	(−59.89)
28	100	18.2 ± 4.1	17.3 ± 6.7	13.0 ± 6.6	11.0 ± 6.4	11.8 ± 6.0	10.2 ± 4.6
			(−4.95)	(−28.57)	(−39.56)	(−35.17)	(−43.96)
35	10	20.5 ± 7.1	13.1 ± 6.4*	10.7 ± 5.7	5.6 ± 3.1*	5.4 ± 3.4*	5.7 ± 3.1*
			(−36.10)	(−47.81)	(−72.68)	(−73.66)	(−72.20)
35	30	21.6 ± 4.4	12.0 ± 3.7*	10.5 ± 5.1	6.3 ± 4.3	5.7 ± 6.7*	5.5 ± 5.2*
			(−44.44)	(−51.39)	(−70.83)	(−73.61)	(−74.54)
35	100	20.3 ± 4.4	15.1 ± 5.0	10.5 ± 4.9	7.2 ± 2.6	7.2 ± 3.9	6.4 ± 2.0*
			(−25.62)	(−48.28)	(−64.53)	(−64.53)	(−68.47)

Each value is the mean ± SEM for six mice in each group.

^*p < 0.05 significantly different ANOVA followed by Dunnett’s t-test for comparison with respect to initial levels in each group.

% Variation of glycemia are in parentheses.