. 2018 Sep 21;2(11):1331–1343. doi: 10.1002/hep4.1233

Table 4.

Comparison Between AUROC Curve of MELD and Other Cox Regression Models for Differentiation Between TFS Versus T/D

Parameters	AUROC	95% CI		Sensitivity	Specificity	PPV	NPV	Accuracy	P	P ^*,†,‡,§	P ^\|\|
		Lower	Upper	(%)	(%)	(%)	(%)	(%)
MELD^*	0.77	0.63	0.87	92	55	57	92	70	0.0009	‐	‐
4COL7S	0.73	0.59	0.84	77	63	57	81	68	0.0012	‐	0.6553
MELD + 4COL7S^*, ^¶	0.83	0.71	0.90	69	85	75	81	79	<0.0001	0.3419^*	0.2419
MELD + Age^†, ^¶	0.84	0.73	0.91	58	95	88	78	80	<0.0001	‐	0.1576
MELD + Age + 4COL7S^†, ^¶	0.89	0.76	0.95	88	83	77	92	85	<0.0001	0.0497^†	0.0135
MELD + ln[NH₃]^‡, ^¶	0.83	0.73	0.90	92	73	69	95	80	<0.0001	‐	0.1537
MELD + ln[NH₃] + 4COL7S^‡, ^¶	0.90	0.79	0.95	92	73	69	95	80	<0.0001	0.0118^‡	0.0083
MELD + Age + ln[NH₃]^§, ^¶	0.90	0.79	0.95	96	70	68	97	80	<0.0001	‐	0.0032
MELD + Age + ln[NH₃] + 4COL7S^§, ^¶	0.93	0.82	0.97	88	90	85	92	89	<0.0001	0.0855^§	0.0008

Statistics were evaluated in 66 non‐acetaminophen‐associated ALF cases with available 4COL7S levels. ^*,†,‡,§Significance with comparison between corresponding Cox regression models inclusive or exclusive of 4COL7S (by DeLong method); ^||significance with comparison to MELD (by DeLong method); ^¶details of each Cox regression model in Supporting Table S3. P < 0.05 was significant.

Abbreviations: CI, confidence interval; NPV, negative predictive value; PPV, positive predictive value; T‐Bil, total bilirubin.