Figure 2.

Domain organization and structure of RAF family members. (A) Domain organization of ARAF, BRAF, CRAF, and kinase suppressor of (activated) RAS (KSR) with features of interest labeled. (B) Model of BRAF kinase domain (based on chain B form PDB code 4MNE) with adenosine triphosphate (ATP) docked in and V600E mutation modeled. Regions of interest are labeled and colored green. (C) Comparison of BRAF-mitogen-activated protein kinase (MEK) heterotetramer (left, in green and orange, respectively; PDB code 1MNE) and the KSR-MEK heterotetramer (right, in blue and orange, respectively; PDB code 2Y4I).