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BRAF inhibitor-binding modes. (A) Cartoon images of BRAF wild-type and β3-αC deletion mutants bound to type I, type I.5, and type II inhibitors, including the effect on αC-helix and the catalytic salt bridge. (B) Cartoon representations of BRAF bound to type I (left), type I.5 (center), and type II inhibitors (right), including the effect on the αC-helix and the catalytic salt bridge.
