Table 1.

BRAF, MEK, and ERK inhibitors with their binding modes defined with structures shown below

Molecule	Target	Binding mode	αC-helix “in” or “out”
GDC-0879	BRAF	Type I	“in”
Vemurafenib	BRAF	Type I.5	“out”
Dabrafenib	BRAF	Type I.5	“out”
PLX-8394	BRAF	Type I.5	“out”
Sorafenib	BRAF	Type II	“in”
AZ-628	BRAF	Type II	“in”
Trametinib	MEK	Class I	“out”
Cobimetinib	MEK	Class I	“out”
GDC-0623	MEK	Class II	“out”
G-573	MEK	Class II	“out”
CH5126766	MEK	Class II	“out”
GDC-0994	ERK	Type I	“in”
SCH772984	ERK	Type I	“in”

MEK, Mitogen-activated protein kinase; ERK, extracellular signal-related kinase.