Fig. 5.

Actively expressed gene promoters are not associated with the nuclear lamina and Pc. a Promoters (distal TSSs) of ubiquitously expressed genes are mainly localized in the conserved HP1a, Lam or Pc inter-domains. The percentage of ubiquitously expressed gene promoters residing in the non-conserved inter-domains (blue), conserved inter-domains (red) or conserved domains (black) is indicated. Regions common to the central brain, neurons, glia, fat body and Kc167 cells are operationally determined as conserved. b Screenshot from UCSC genome browser showing an example of the gene CG13579, which is specifically expressed in neurons, with the dip of the neuronal log₂(Dam-Lam/Dam) profile at the TSS region. Note that due to imperfectness of domain calling algorithm no gap in the HMM-determined Lam domain (black rectangle over profile) is seen. c Plotted are the median values of neuronal log₂(Dam-POI/Dam) profiles (where POI is Lam, Pc or HP1a) around promoters (distal TSSs) of the genes separated according to their neuronal expression level into four groups