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. 2018 Nov 1;18:1058. doi: 10.1186/s12885-018-4952-y

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© The Author(s). 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Proteomic analysis of small-EVs from HCT-116 and HT-29 colon cancer cells. Search results were identified using MASCOT software. a At the cut-off settings, 464 human proteins were identified; of these, 176 proteins were observed to be common between the two cell lines. In total, 140 proteins were uniquely identified in the HCT-116-derived small-EVs and 148 proteins were identified in the HT-29-derived small-EVs. Among these, 415 proteins were present in the ExoCarta database. Identified proteins were segregated into various groups using PANTHER software. Gene ontology analysis for molecular function b, biological process c, cellular component d, protein class e, and pathway f of the proteins identified in small-EVs was performed using PANTHER software