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. 2018 Nov 1;18:1058. doi: 10.1186/s12885-018-4952-y

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© The Author(s). 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Diagnostic value of TSPAN1-positive EVs in plasma. a TSPAN1-positive small-EVs in plasma were captured using the coated anti-CD63 antibody and detected using the anti-TSPAN1 antibody. b TSPAN1-positive small-EVs were validated in the plasma of colon cancer patients (CC, n = 37) and healthy controls (HC, n = 30). Significance was analyzed using the Mann-Whitney test. ****p < 0.0001. c ROCs for differentiating between CC patients and HCs were analyzed. The AUC, sensitivity, and specificity for TSPAN1 are shown