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. 2018 Nov 1;18:1059. doi: 10.1186/s12885-018-4966-5

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Genetic alterations used as predictive biomarkers for APL patients. a Chromosomal translocations between RARA and several fusion partners playing an important role in maintaining resistance/sensitivity of APL patients to retinoids [122]. b Breakpoint cluster regions (bcr) in PML gene resulting in alternative splicing and different therapeutic response to ATRA in APL patients. E5(−)E6(−) isoform of L-type fusion transcript with exons 5 and 6 deleted is associated with the ATRA-resistant phenotype