Fig. 2.

Schematic presentation of the GDH pathway. Synthesis of glutamate occurs through the action of NADP-GDH (encoded by GDH1 and GDH3 genes). NAD-GDH activity (encoded by GDH2) is responsible for glutamate degradation and release of ammonium and α-ketoglutarate. GDH2 glutamate dehydrogenase 2