Table 2.

Genotype distribution in cases and controls of the eligible studies

First author	Year	Cases			Controls			HWE in controls	MAF (cases/controls)
		GG	GA	AA	GG	GA	AA
Maillet P [45]	2000	34	13	0	120	40	3	0.874	0.138 / 0.141
Dork T [34]	2001	753	235	12	422	74	4	0.705	0.130 / 0.082
Sommer SS [17]	2002	38	5	0	32	11	0	0.336	0.058 / 0.128
Angele S [33]	2003	240	65	7	192	56	6	0.433	0.127 / 0.134
Bretsky P [22]	2003	335c		47	329c		47	NA	NA
Angele S [53]	2004	457	153	18	309	124	12	0.917	0.150 / 0.166
Buchholz TA [37]	2004	39	17	2	394	119	15	0.107	0.181 / 0.141
Kristensen AT [46]	2004	99	50	2	2413	1008	105	0.983	0.179 / 0.173
Heikkinen K [35]	2005	68	44	9	174	109	23	0.308	0.256 / 0.253
Landi S [47]	2006	205	73	7	238	63	3	0.602	0.153 / 0.113
Renwick A [36]	2006	339	98	6	371	131	19	0.088	0.124 / 0.162
Tommiska J a [29]	2006	485	285	33	404	260	38	0.648	0.219 / 0.239
Tommiska J b [29]	2006	469	276	33	404	260	38	0.648	0.220 / 0.239
Wu X [48]	2006	434	156	18	439	136	17	0.109	0.158 / 0.144
Yang H [21]	2007	537c		7	536c		10	0.590	NA
Gonzalez-Hormazabal P [18]	2008	100	26	0	174	26	0	0.326	0.103 / 0.065
Hirsch AE [23]	2008	29c		8	78c		17	NA	NA
Margulis V [54]	2008	254	64	5	249	81	5	0.583	0.115 / 0.136
Schrauder M [32]	2008	406	99	9	369	129	13	0.668	0.114 / 0.152
Tapia T [31]	2008	74	19	1	183	15	2	0.015	0.112 / 0.048
Akulevich NM a [30]	2009	95	25	2	138	53	7	0.501	0.119 / 0.169
Akulevich NM b [30]	2009	105	24	3	293	90	15	0.020	0.114 / 0.151
Li D [52]	2009	524	186	18	565	200	8	0.034	0.152 / 0.140
Oliveira S [43]	2011	113	31	5	194	79	7	0.755	0.138 / 0.166
Al-Hadyan KS [49]	2012	131	23	2	218	33	0	0.265	0.087 / 0.066
Xu L a [24]	2012	239	64d		392	119d		> 0.05	NA
Xu L b [24]	2012	244	45d		305	69d		> 0.05	NA
Alsbeih G [42]	2013	90	8	2	88	12	0	0.523	0.060 / 0.060
Pena-Chilet M [50]	2013	349	91	9	232	68	11	0.040	0.121 / 0.145
Calderon-Zuniga Fdel C [20]	2014	82	12	0	96	0	0	NA	0.060 / 0.000
Damiola F [39]	2014	63	6	1	177	66	7	0.778	0.057 / 0.160
Wojcicka A [38]	2014	1261	319	23	1455	357	32	0.066	0.114 / 0.114
Maillard S [19]	2015	164	11	0	262	8	0	0.805	0.031 / 0.015
Pereda CM [41]	2015	153	44	0	162	42	2	0.690	0.112 / 0.112
Tecza K [51]	2015	153	64	6	254	76	5	0.800	0.170 / 0.128
Halkova T [40]	2016	158	45	5	284	81	9	0.270	0.132 / 0.132
Al-Harbi NM [44]	2017	201	28	3	275	38	0	0.253	0.073 / 0.061

HWE, hardy-weinberg equilibrium; MAF, minor allele frequency; NA, data was unavailable

^a,bTwo independent case-control studies were presented for the same original study

^cnumber of GG + GA

^dnumber of GA + AA