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. 2018 Nov 1;16:86. doi: 10.1186/s12951-018-0415-5

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Histological observation of the colon: a colon length; b representative images of the measurements of colon length; c histological scores and d typical images of H&E stained colonic sections. Each point in a and c represents a single sample. Asterisks and plus signs represent significant differences (***P < 0.001, ⁺⁺⁺P < 0.001, ⁺⁺P < 0.01, ⁺P < 0.05, Dunnett’s post hoc test following ANOVA) versus the normal control and the DSS control, respectively. Different lower-case letters mark significant differences (P < 0.05, ANOVA followed by LSD test) between AuNP-treated groups