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. 2018 Nov 1;16:86. doi: 10.1186/s12951-018-0415-5

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — The effects of orally administered AuNPs on global gut microbiota structures: a the α-diversity metric ACE; b the unweighted UniFrac metric; c PCA analysis of β-diversity based upon the unweighted UniFrac distances, where each point represents a single sample with the percentages indicating the contribution of principal components to the difference of samples; d the ratios of Firmicutes to Bacteroidetes. The comparison is made by Wilcox’s test, and significant P-value is marked as *P < 0.05