Fig. 2.

Serum restriction sensitizes ALL to vincristine treatment. a Viable 8093 cells after 72 h in culture media with various concentrations of FBS, alone, or with 10 nM VCR (n = 3). b Dose response of murine ALL 8093 cells cultured with VCR in 5 or 10% FBS (n = 4). c Viable 8093 cells after culture alone or with 10 nM VCR (n = 7) ***p < 0.001, two-sided, paired t test. d EC₅₀ values calculated from dose responses of vincristine with all three cell lines; connecting lines show paired experiments. *p < 0.05, ***p < 0.001, two-sided, paired t test. e, f Dose response of human ALL cell lines BV173 (e) and Nalm6 (f) with VCR in 5 or 10% FBS (n = 4)