Figure 4.

Overlap with GWAS. (A) Integration of prediction, BiT-BUNDLE-seq, BiT-STARR-seq, and GWAS results for Crohn's disease risk variant rs3810936. Triangles represent transcription factors. (B) A comparison of allelic effects from computational prediction to phenotype for rs3810936. Predicted log odds score is the reference prior log odds–alternate log odds from the CentiSNP annotation. BiT-BUNDLE-seq Z-score is the Z-score from the metaanalysis of ASB from all three concentrations of NFKB1. BiT-STARR-seq Z-score is the Z-score from metaanalysis of ASE for nine experimental replicates. GWAS OR is the odds ratio from rs3810936 alternate allele with Crohn's disease (Yamazaki et al. 2005; Franke et al. 2010; Baskaran et al. 2014; Lee et al. 2015). All scores are signed relative to the risk allele, which is the alternate allele.