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. 2018 Nov;28(11):1601–1610. doi: 10.1101/gr.220780.117

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© 2018 Xiao et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 4. — Functional studies of up-regulated autophagy-lysosomal genes in IMR-90 cells and transgenic flies. (A) Protein levels of SQSTM1 in IMR-90 cells with overexpressed CTSB, ATP6V0C, ATG4D, and WIPI1, respectively. (B) The SA-β-Gal staining cell ratio in IMR-90 cells with overexpressed CTSB, ATP6V0C, ATG4D, and WIPI1, respectively. (C) Cumulative cell population doubling of IMR-90 with overexpressed CTSB, ATP6V0C, ATG4D, and WIPI1. (D) Protein levels of CDKN2A and CDKN1A in IMR-90 cells with overexpressed CTSB, ATP6V0C, ATG4D, and WIPI1, respectively. (E) Diagram of Gal4-UAS system in flies. (F) Survival curve of Drosophila with overexpressed Atg18a. (*) P < 5.0 × 10⁻². (OE) Overexpression.