Table 3. ROC curve analysis of the individual genes.

Model Name	Associated Criteria	Sensitivity	Specificity	Significance P (area = 0.5)	Youden Index J	Area under the curve	95% CI
CD44v6	>27.66519140	96.87	90	<0.0001	0.8688	0.965	0.884 to 0.995
CXCL12	≤1.578258295	100	100	<0.0001	1	1	0.942 to 1.000
CXCR4	≤6.535661813	65.62	70	0.0147	0.3563	0.671	0.540 to 0.785
CDH1	≤0.901250463	90.62	100	<0.0001	0.9063	0.992	0.927 to 1.000
CDKN2A	≤2.060984041	53.13	93.33	0.0103	0.4646	0.682	0.552 to 0.795
CK7	≤0.649169294	100	100	<0.0001	1	1	0.942 to 1.000
CLDN4	>17.28761168	46.88	100	0.0048	0.4688	0.699	0.569 to 0.809
CTNNB1	≤0.698984967	96.87	100	<0.0001	0.9688	0.997	0.936 to 1.000
HIF1A	≤0.766664172	96.87	96.67	<0.0001	0.9354	0.996	0.934 to 1.000
MMP9	>40.36407708	34.38	90	0.2545	0.2438	0.584	0.452 to 0.708
MUC16	>1.972465409	96.87	100	<0.0001	0.9688	0.995	0.930 to 1.000
OPN	>13.70534430	40.63	76.67	0.8689	0.1729	0.512	0.382 to 0.642
TP53	>57.81345285	40.63	76.67	0.8904	0.1729	0.510	0.380 to 0.640
TGFBR2	≤0.105112052	90.62	53.33	<0.0001	0.4396	0.774	0.650 to 0.871
VEGFA	≤0.23815950	81.25	66.67	0.0159	0.4792	0.678	0.547 to 0.791