Fig 2. Hypothetical dual mechanism of the AGT rs5050 genetic variant.

The 5´ upstream core promoter region of the human AGT gene, where rs5050 is identified, has been recognized as an authentic regulator for the transcription of AGT mRNA [38]. Differences in the AGT plasma levels were found between the genotypes of rs5050, with the GG-genotype associated with the lowest levels [22]. AGT expresses opposite effects, showing an antiangiogenic property, such as some Serpins family members, and a proangiogenic activity as the precursor of AngII. It might depend upon local conditions that define which of the effects dominates [48].