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. Author manuscript; available in PMC: 2019 Oct 10.
Published in final edited form as: Neuron. 2018 Oct 10;100(1):75–90.e5. doi: 10.1016/j.neuron.2018.09.014

Figure 3.

Figure 3

Progressive motor deficits in tetramer-deficient 3K αS tg mice. (a) Stacked images to assess spontaneous head and body tremor in 3K mice at 6 mo by videography and ImageJ software (representative images of n=2 3K and WT). (b) Limb clasping in 3K (n=8) vs. WT (n=10) αS tg mice at 1–6 mo. (c) Quant. of the tests in a and b (Methods). (d) Stacked images of a single WT and a single 3K mouse during the pole test show typical abnormal climbing and subsequent fall of a 3K mouse after turning around to climb down. (e) Graphs quantify time to descend the pole and number of falls in 3 mo and 6 mo mice. Left graphs quantify spontaneous exploration in an open field (OF) chamber and fine motor and balancing skills in a 4–40 rpm accelerating rotarod test. Means ± SEM. *p<0.05, **p<0.01; ***p<0.001. (c) (tremor range and contour sharpness): unpaired 2-tailed Student’s t test, or else one-way ANOVA, post Tukey.