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. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: Drug Alcohol Depend. 2018 May 31;189:42–48. doi: 10.1016/j.drugalcdep.2018.04.032

Table 3:

Multiple linear regression models to predict e-liquid consumption and nicotine intake and exposure from vaping topography parameters.

Dependent variable E-liquid Predictor Estimate (SE) β coefficient p-value R2
Liquid consumed (mg) † Strawberry Puff count 8.1 (2.3) 1.42 0.006 0.73
Puff duration 58.6 (26.6) 0.37 0.052
Inter-puff interval 2.7 (1.7) 0.65 0.16
Tobacco Puff count 4.5 (1.3) 0.99 0.005 0.89
Puff duration 72.8 (26.8) 0.38 0.022
Inter-puff interval 0.80 (0.88) 0.25 0.39
Usual Puff count 5.3 (2.3) 0.91 0.046 0.63
Puff duration 38.8 (50.4) 0.16 0.46
Inter-puff interval 1.46 (3.72) 0.17 0.70
E-liquid [nicotine] −16.6 (16.8) −0.23 0.35
Nicotine inhaled (mg) † Strawberry Puff count 0.14 (0.04) 1.42 0.006 0.73
Puff duration 1.01 (0.46) 0.37 0.052
Inter-puff interval 0.05 (0.03) 0.65 0.16
Tobacco Puff count 0.08 (0.02) 0.99 0.005 0.89
Puff duration 1.23 (0.45) 0.38 0.022
Inter-puff interval 0.01 (0.01) 0.25 0.39
Usual Puff count −0.004 (0.013) −0.15 0.75 0.47
Puff duration 0.41 (0.30) 0.34 0.20
Inter-puff interval −0.04 (0.02) −1.02 0.08
E-liquid [nicotine] 0.38 (0.10) 1.06 0.004
Cmax (ng/mL) Strawberry Puff count 0.29 (0.25) 0.87 0.26 0.09
Puff duration 2.05 (2.87) 0.22 0.49
Inter-puff interval 0.10 (0.19) 0.40 0.62
Tobacco Puff count 0.13 (0.10) 0.68 0.21 0.61
Puff duration 3.69 (2.06) 0.46 0.10
Inter-puff interval 0.01 (0.07) 0.08 0.88
Usual Puff count −0.02 (0.04) −0.21 0.65 0.50
Puff duration 1.23 (0.96) 0.30 0.23
Inter-puff interval −0.13 (0.07) −0.89 0.11
E-liquid [nicotine] 1.30 (0.32) 1.08 0.003
AUC(0→90) (ng/mL•min) Strawberry Puff count 13.7 (12.0) 0.83 0.28 0.10
Puff duration 125.5 (139.2) 0.28 0.39
Inter-puff interval 4.2 (9.2) 0.36 0.65
Tobacco Puff count 7.3 (5.2) 0.75 0.19 0.59
Puff duration 161.3 (110.0) 0.39 0.17
Inter-puff interval 0.8 (3.6) 0.12 0.83
Usual Puff count 0.5 (2.8) 0.09 0.85 0.41
Puff duration 97.6 (62.8) 0.40 0.15
Inter-puff interval −4.7 (4.6) −0.55 0.34
E-liquid [nicotine] 73.7 (20.9) 1.02 0.006

Note: E-liquid [nicotine] is measured e-liquid nicotine concentration in mg/mL;

†

statistics are identical for amount of e-liquid consumed and amount of nicotine inhaled for the strawberry and tobacco e-liquids, respectively, because the nicotine concentration of each of these e-liquid was fixed during the study. Amount of nicotine inhaled is a function of amount of e-liquid consumed and e-liquid nicotine concentration.