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. Author manuscript; available in PMC: 2019 Jun 11.
Published in final edited form as: Biomacromolecules. 2018 Apr 30;19(6):1764–1782. doi: 10.1021/acs.biomac.8b00276

Figure 9.

Figure 9.

(a) The composite core-shell scaffolds resemble the native structure of skeletal muscle tissue, consisting of aligned myofibers surrounded within extracellular connective tissue. (b) Preparation scheme of core-shell sheet scaffolds that mimic the native skeletal muscle tissue by the combination of aligned nanofiber yarns (NFYs) and hydrogel shell of poly(ethylene glycol)-co-poly(glycerol sebacate) (PEGS-M) solution. SEM images (c) of aligned NFYs core and hydrogel shell of the core-shell sheet scaffold after lyophilization. (d) The merged image of aligned NFYs cores exhibited overspreading C2C12 myotubes within the hydrogel sheet. (e) The 3D side view of the core-shell scaffolds containing highly organized myotubes. Reprinted with permission from reference 51. Copyright 2015 American Chemical Society.