Figure 4. The Nuclear Receptor Ring of Physiology.

The relationship between receptor expression, function, and physiology is depicted as a circular dendrogram using the hierarchical, unsupervised clustering of NR tissue expression distribution profiles obtained from Figure 2. The analysis reveals the existence of a higher-order network tying nuclear receptor function to reproduction, development, central, and basal metabolic functions, dietary-lipid metabolism, and energy homeostasis.