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Aromatase and pERα are upregulated in the absence of SRD5A2. (A) Representative figures for protein expression by immunoblot assay. Patients 1, 2 and 3 represent SRD5A2-unmethylated samples; patients 4, 5 and 6 represent 5RD5A2-methylated samples. (B) Representative pictures of immunohistochemical analyses demonstrating increased levels of pERα and aromatase when SRD5A2 expression was absent. GAPDH, glyceraldehyde-3-phosphate dehydrogenase.
