Figure 1.

Illustration of the deterministic tractography used for the analyses. For amygdalothalamic tract (E), we seeded our first region of interest (ROI) (OR operator in DTIstudio) in the commissural fibers (red), best seen in approximately 13 mm off-midline sagittal, inferior to the antero-inferior tips of the fornix fimbria (pointed by arrow), posterior to projection fibers (blue) and anteroinferior to corpus callosum isthmus and splenium parts (A) and second ROI (AND operator) in temporal lobe coronal section at the level of anterior commissure (B). For orbitofrontothalamic tract (F) we seeded our first ROI (OR operator) (C) on the midline association fibers (green) coronally which is dorsolateral thalamus, bordered by a triangle; projection fibers bilaterally and corpus callosum and fornix at the top and second ROI (AND operator) in medial frontal pole where orbitofrontal cortex located (D). NOT operator was used to clean the contaminations of other pathways and it was performed in varying degree in subjects by neuroanatomy guidance. The seeds were placed on one slice for each operator. DTIStudio and DSIStudio (http://dsi-studio.labsolver.org/) were used to generate this figure. Illustration maps are color-coded map (A–D) and T1weighted (E–F) maps. Abbreviations: ATT: amygdalothalamic tract, DMT: dorsolateral thalamus, OFT: orbitofrontothalamic tract.