Table 1. Driving pressure and mortality in 7 randomised trials in ARDS patients.
| Study | Intervention vs. control | Intervention | Control | Mortality | |||
|---|---|---|---|---|---|---|---|
| N | ∆P | N | ∆P | ||||
| Brower 2004 (49) | Higher vs. lower PEEP | 264 | 12.3 (6.9) | 249 | 15.1 (7.8) | n.s. | |
| Mercat 2008 (50) | Higher vs. lower PEEP | 380 | 12.9 (4.0) | 372 | 14.0 (5.0) | n.s. | |
| Meade 2008 (51) | Higher PEEP + RM vs. lower PEEP | 471 | 14.6 (7.4) | 507 | 14.8 (5.9) | n.s. | |
| Xi 2010 (52) | RM vs. no RM | 55 | 13.7 (6.2) | 55 | 13.6 (5.8) | n.s. | |
| Hodgson 2011 (53) | Higher PEEP + RM vs. lower PEEP | 10 | 12.6 (5.7) | 10 | 16.9 (4.7) | n.s. | |
| Kacmarek 2016 (54) | Higher PEEP + RM vs. lower PEEP | 94 | 12.1 (5.4) | 101 | 13.6 (5.2) | n.s. | |
| Cavalcanti 2017 (46) | Higher PEEP + RM vs. lower PEEP | 481 | 11.7 (6.0) | 490 | 13.4 (6.1) | Higher with PEEP + RM | |
Data of ∆P are presented as mean (SD). N = number of patients included in the intervention or control group. ARDS, acute respiratory distress syndrome; PEEP, positive end-expiratory pressure; ∆P, driving pressure; RM, recruitment manoeuvre; n.s., no significant differences in mortality between intervention and control group.