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. 2018 Nov 1;8:16220. doi: 10.1038/s41598-018-34474-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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CD98 overexpression in IECs alter unique miRNAs associated with villus-crypt axis profile. All miRNAs listed were found to be differentially expressed using a cutoff p-value of <0.05. A total of 119 miRNAs were differentially expressed along the villus-crypt axis of WT and Tg ileal IECs. Among them, there was an overlap of 37 miRNAs found to be similarly expressed in both genotypes while 39 miRNAs and 43 miRNAs were uniquely distributed along the axis to either WT or Tg, respectively. miRNAs listed reflect the directional expression found in villus compared to crypt along the axis of the same genotype. The left column of each grouping is the downregulated miRNAs, whereas the right column represents upregulated miRNAs in the villus.