Table 2.

Taste system recovery from HH Pathway Inhibition (HPI) by sonidegib drug removal.

Taste Effect	Mouse Anterior Tongue	Mouse Posterior tongue
Recovery from 16 days of HPI with sonidegib
Papilla morphology	~50% of FP recovered normal structure3	CV depth and wall length maintained3
TB count	Recovered in ~50% of total FP3	Complete recovery after 40% loss of TB3
Nerve response to chemicals	CT nerve responses returned to Vehicle levels3	Not done
Recovery from 48 days of HPI with sonidegib
Papilla morphology	No recovery after >95% loss of typical FP structure	CV wall length retained, alterations in depth did not recover
TB count	No recovery after >95% loss of TB	Complete recovery

Recovery effects are summarized and compared between anterior and posterior tongue papillae and TB in mice after 16d or 48d of sonidegib treatment, followed by several months with no drug. All results are from the current paper, except where data are referenced with literature citations.