Table 3.

Summary of cases that developed radiation-induced liver disease after the first and second SBRT.

Case	Timing	Pre-SBRT C–P class (score)	Dose fractionation	Normal liver volume	Cumulative MLD	Hepatotoxicity	Post-SBRT C–P class (score)
67/M	First	A (5)	60 Gy/3fx	1274 cm3	5.7 Gy	Gr 3 (AST/ALT)*	A (5)
70/M	Second	B (7)	45 Gy/3fx	1139 cm3	12.5 Gy	Gr 3 (Bilirubin)	C (12)*
58/M	Second	B (7)	45 Gy/3fx	794 cm3	19.3 Gy	Gr 2 (Bilirubin)*	B (9)*

Abbreviations: SBRT, stereotactic body radiation therapy; C–P, Child–Pugh; MLD, mean liver dose; Gr, grade; AST, aspartate aminotransferase; ALT, alanine aminotransferase.

^*Toxicities that meet the pre-defined criteria of radiation-induced liver disease.