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. 2018 Nov 1;8:16165. doi: 10.1038/s41598-018-34490-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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NPT200-11 administration decreased ASYN immunolabeling of cortical neuropil and neurons in the Line 61 ASYN transgenic mouse. There was a statistically significant increase in (a) ASYN immunolabeling in the cortical neuropil and (b) number of ASYN immunolabeled neuronal cell bodies of Line 61 ASYN transgenic mice (****p < 0.0001 vs. non-transgenic/vehicle controls). NPT200-11 administration (1 & 5 mg/kg) produced statistically significant reductions in transgenic ASYN levels in the (a) cortical neuropil (^####p < 0.0001 vs. Line 61 ASYN transgenic/vehicle controls), and a trend (p = 0.0523) for reduction in cortical neuropil of Line 61 transgenic ASYN levels in mice treated with 0.5 mg/kg NPT200-11. NPT200-11 administration (5 mg/kg) produced a statistically significant reduction in (b) the number of ASYN immunopositive neuronal cell bodies in the cortex of Line 61 ASYN transgenic mice (^##p < 0.01 vs. Line 61 ASYN transgenic/vehicle controls). Representative images obtained at 40x are shown in (c), where the scale bar represents 40 microns.