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. 2018 Nov 2;7(11):83. doi: 10.1038/s41389-018-0093-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Compound BDF-1253 inhibited the proliferation of RCC 786-O cells, with an IC₅₀ value of 1.508 μM for the treatment of 7 days. b Compound BDF-1253 inhibited the proliferation of RCC Caki cells, with an IC₅₀ value of 3.574 μM for the treatment of 7 days. c Compound BDF-1253 inhibited the proliferation of RCC ACHN cells, with an IC₅₀ value of 2.067 μM for the treatment of 7 days. d Compound BDF-1253 inhibited the proliferation of RCC A498 cells, with an IC₅₀ value of 1.393 μM for the treatment of 7 days. e Compound BDF-1253 effectively inhibited the proliferation of four RCC cell lines, without obvious cytotoxic effects against normal cells. Data were represented relative to DMSO treatment. a–e Error bars indicate standard deviation among 3 biological replicates. f Significant reduction in tumor size was observed after the treatment of compound BDF-1253 for 21 days, on RCC xenograft mice model. Two-way ANOVA with multiple comparisons was used for comparison. Error bars indicated standard deviation (n = 7 mice in each group). *p < 0.05; **p < 0.01; ***p < 0.001. g Mice body weight was not obviously affected after compound treatment. Statistical significance relative to the control group was assessed using one-way ANOVA. ns indicated not significant. h Compound treatment reduced expression of BET downstream effector c-Myc and Bcl-2 in vivo