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. 2018 Nov 1;8:16184. doi: 10.1038/s41598-018-34554-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Influence of SUM forms on tactile allodynia (A) and thermal hyperalgesia (B) in a mouse model of migraine pain induced by nitroglycerin (NTG) administration. Results are shown as mean paw withdrawal forces (±SEM) measured in the von Frey test (A), or latency time to pain reaction (±SEM) measured in the hot plate test (B) for n = 8–10. Statistical analysis: analysis of variance (ANOVA), followed by Tukey’s post hoc test. Significance vs. baseline (i.e. before nitroglycerin administration) paw withdrawal force, or latency time to pain reaction: ^#p < 0.05, ^###p < 0.001. Significance vs. pre-drug (i.e. before SUM form administration) measurement: *p < 0.05, ***p < 0.001.