Table 1.
Spectrum of pathological observations in Kif14 transgenic (Tg) mice versus wild-type (wt) littermates.
| Pathology | Observed | Cause of death | ||||
|---|---|---|---|---|---|---|
| wt | Kif14 Tg | p | wt | Kif14 Tg | p | |
| lymphoma | 34 (74) | 35 (85) | 0.29 | 23 (50) | 30 (73) | 0.03 |
| follicular lymphoma | 14 (30) | 19 (46) | 10 (22) | 16 (39) | ||
| diffuse B cell lymphoma | 12 (26) | 12 (29) | 9 (20) | 11 (27) | ||
| thymic lymphoma | 5 (11) | 3 (7) | 4 (9) | 3 (7) | ||
| lacrimal gland lymphoma | 2 (4) | 0 (0) | 0 (0) | 0 (0) | ||
| unspecified lymphoma | 1 (2) | 1 (2) | 0 (0) | 0 (0) | ||
| sarcoma | 4 (9) | 7 (17) | 0.34 | 4 (9) | 6 (15) | 0.51 |
| undifferentiated sarcoma | 1 (2) | 2 (5) | 1 (2) | 1 (2) | ||
| histiocytic sarcoma | 1 (2) | 3 (7) | 1 (2) | 3 (7) | ||
| hemangiosarcoma | 1 (2) | 1 (2) | 1 (2) | 1 (2) | ||
| fibrosarcoma | 1 (2) | 0 (0) | 1 (2) | 0 (0) | ||
| lung sarcoma | 0 (0) | 1 (2) | 0 (0) | 1 (2) | ||
| carcinoma | 8 (17) | 2 (5) | 0.09 | 6 (13) | 1 (2) | 0.11 |
| hepatocellular carcinoma | 2 (4) | 1 (2) | 2 (4) | 0 (0) | ||
| adenocarcinoma | 4 (9) | 0 (0) | 2 (4) | 0 (0) | ||
| spindle cell carcinoma | 1 (2) | 0 (0) | 1 (2) | 0 (0) | ||
| abdominal carcinoma | 1 (2) | 0 (0) | 1 (2) | 0 (0) | ||
| ductal carcinoma | 0 (0) | 1 (2) | 0 (0) | 1 (2) | ||
| myeloid dysplasia | 5 (11) | 7 (17) | 0.54 | 1 (2) | 1 (2) | 1.0 |
| pituitary tumour | 4 (9) | 2 (5) | 0.41 | 4 (9) | 1 (2) | 0.18 |
| hydronephrosis | 15 (33) | 16 (39) | 0.65 | 3 (7) | 2 (5) | |
| ballooning lens degeneration | 0 (0) | 5 (12) | 0.02 | 0 (0) | 0 (0) | |
| hemangioma | 2 (4) | 1 (2) | 1.0 | 1 (2) | 0 (0) | |
| adenoma | 3 (7) | 5 (12) | 0.47 | 1 (2) | 0 (0) | |
Data are stratified into animals in which a pathology was observed, and the subset of animals in which that pathology was the cause of death. Note that some animals exhibited multiple pathologies. Number of animals and (% of total necropsied) per genotype indicated (N = 46 for wt, 41 for Kif14 Tg). Fisher’s exact test p-values for comparing genotypes shown; significant differences are bold and italicized.