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. 2018 Oct 26;8:483. doi: 10.3389/fonc.2018.00483

Figure 1.

Figure 1

FoxM1 promotes tumor carcinogenesis and proliferation in nasopharyngeal carcinoma (NPC) (A,B). FoxM1 expression in NPC and non-cancerous nasopharyngeal tissues based on IHC. Weak FoxM1 expression in non-tumoral pharynx epithelium and strong staining in NPC samples (C,D). The expression of FoxM1 in 6-10B and SUNE1 cells carrying FoxM1 transgene and 5-8F with stably FoxM1 knockdown by qRT-PCR and Western blot, respectively (E). The cell growth rates were determined by CCK8 assay (F). Colony formation of 6-10B and SUNE1 cells with or without exogenous FoxM1 expression. The assay was performed in triplicate (G,H). The cell cycle distribution in overexpressing-FoxM1 SUNE1 and siFoxM1 5-8F cells by FACS. Histograms showing the changes of G1/S phase S phase in SUNE1 and 5-8F cells after overexpressing and knockdown FoxM1 gene, respectively. *P < 0.05; **P < 0.01.