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. 2018 Oct 26;6(12):521–530. doi: 10.12998/wjcc.v6.i12.521

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©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Receiver operating characteristic curve analysis of non-invasive tests for prediction of liver fibrosis stages (S2-4) in the different alanine aminotransferase groups. A-C: Predicting liver fibrosis in the normal alanine aminotransferase (ALT) group; A: For significant fibrosis (≥ S2); B: For advanced fibrosis (≥S3); C: for cirrhosis (S4); D-F: Predicting liver fibrosis in the slightly elevated ALT group; D: For significant fibrosis (≥ S2); E: For advanced fibrosis (≥ S3); F: For cirrhosis (S4); G-I: Predicting liver fibrosis in the elevated ALT group; G: For significant fibrosis (≥ S2); H: For advanced fibrosis (≥ S3); I: For cirrhosis (S4). GPR: Gamma-glutamyl transpeptidase (GGT)-to-platelet ratio; APRI: Aspartate aminotransferase (AST)-to-platelet (PLT) ratio index; FIB-4: Fibrosis index based on 4 factors.