Table 1.
Baseline characteristics of the subjects
| Characteristics | Total group (n = 599) | ALT ≤ 40 group (n = 272) | 40 < ALT ≤ 80 group (n = 190) | ALT > 80 group (n = 137) | P-value |
| Age (yr) | 37 (29, 44) | 39 (31.25, 46) | 37.5 (28, 43.25) | 34 (28, 40.5) | < 0.001 |
| Male (%) | 349 (58.3) | 131 (48.2) | 130 (68.4) | 88 (64.2) | < 0.001 |
| ALT (U/L) | 44 (28, 76) | 26 (31, 33) | 56 (48, 66) | 127 (95, 218.5) | < 0.001 |
| AST (U/L) | 32 (24, 48) | 24 (20, 28) | 36 (31, 42) | 70 (55, 115.5) | < 0.001 |
| GGT (U/L) | 25 (17, 41) | 19 (14, 25) | 30 (20, 41.25) | 48 (30, 78) | < 0.001 |
| Cholesterol (mmol/L) | 4.31 (3.84, 4.96) | 4.35 (3.86, 4.95) | 4.24 (3.75, 4.95) | 4.34 (3.84, 4.99) | 0.732 |
| PLT (109/L) | 182 (150, 217) | 184 (155, 223) | 177.5 (145.5, 212) | 180 (149, 215) | 0.215 |
| INR | 1 (1, 1.1) | 1 (1, 1.1) | 1 (0.99, 1.1) | 1 (0.94, 1.1) | 0.4 |
| HBV DNA (log10IU/mL) | 7.03 (4.24, 8.23) | 4.77 (3.32, 7.78) | 7.64 (5.72, 8.23) | 8.03 (6.81, 8.23) | < 0.001 |
| S (%) | |||||
| S0 | 264 (44.1) | 128 (47.1) | 80 (42.1) | 56 (40.9) | |
| S1 | 147 (24.5) | 73 (26.8) | 53 (27.9) | 21 (15.3) | |
| S2 | 96 (16) | 35 (12.9) | 29 (15.3) | 32 (23.4) | |
| S3 | 54 (9) | 19 (7.0) | 18 (9.5) | 17 (12.4) | |
| S4 | 38 (6.3) | 17 (6.3) | 10 (5.3) | 11 (8.0) | |
| Stage S0-1 fibrosis | 411 (68.6) | 201 (73.9) | 133 (70) | 77 (56.2) | 0.001 |
| Stage S2-4 fibrosis | 188 (31.4) | 71 (26.1) | 57 (30) | 60 (43.8) | |
| APRI | 0.53 (0.38,0.86) | 0.38 (0.3, 0.49) | 0.61 (0.44,0.8) | 1.16 (0.88, 1.93) | < 0.001 |
| FIB-4 | 1.02 (0.72,1.47) | 1.02 (0.72,1.37) | 0.96 (0.66,1.55) | 1.22 (0.82, 1.79) | < 0.001 |
| GPR | 0.22 (0.15,0.38) | 0.16 (0.11, 0.23) | 0.24 (0.17,0.38) | 0.42 (0.25, 0.68) | < 0.001 |
| King’s score | 6.77 (4.31,11.49) | 4.89 (3.54,7.03) | 7.18 (4.58,11.58) | 13.04 (9.81, 27.15) | < 0.001 |
| Forns index | 6.48 (5.44,7.51) | 6.33 (5.37,7.37) | 6.57 (5.51,7.69) | 6.65 (5.57, 7.57) | 0.081 |
Data are expressed as the n (%) or median (interquartile range, IQR). ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; GGT: Gamma-glutamyl transferase; PLT: Platelet; S: Stage of fibrosis; GPR: Gamma-glutamyl transpeptidase (GGT)-to-platelet ratio; APRI: Aspartate aminotransferase (AST)-to-platelet (PLT) ratio index; FIB-4: Fibrosis index based on 4 factors; INR: International sensitivity index.