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Possible role of Ser361 phosphorylation and C‐arrestin domain during cell cycle regulation. TXNIP is phosphorylated at Ser361 by p38 MAPK. This phosphorylation could facilitate binding of TXNIP and JAB1. As a result, the association between JAB1 and p27kip1 could weaken, and p27kip1 stably functions as a negative regulator of cyclin E–Cdk2. TXNIP C‐arrestin domain is responsible for its nuclear localization, which is a prerequisite for the function of TXNIP in cell cycle regulation.
