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. 2018 Oct 26;12:387. doi: 10.3389/fncel.2018.00387

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Copyright © 2018 Zhou, Puche and Shipley.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Optical stimulation of ChR2 expressing OCX axons elicits robust excitatory synaptic currents (EPSCs) in GCs. (A) Optically evoked GC EPSCs are blocked by the AMPA/kainate receptor antagonist 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo[f]quinoxaline-2,3-dione (NBQX; 10 μM, n = 5). No change in EPSC was observe with block of NMDA receptors with the antagonist D-2-amino-5-phosphonopentanoic acid (D-AP5; 50 μM, n = 5). The rise time, decay time and peak amplitude was 1.77 ± 0.27 ms, 10.33 ± 1.34 ms and 104.31 ± 14.33 pA in ACSF and 1.71 ± 0.32 ms, 10.02 ± 1.29 ms and 109.8 ± 13.76 pA in D-AP5, respectively, and they were no difference. (B) Representative EPSCs elicited by varying optical power from 0 mW to 4 mW. (C) Curve fitting of the power-response profile shows a linear response from 0 mW to 3 mW with response amplitude plateauing out to 8 mW (n = 5).