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MiR-221/222 directly targets Cx43 in U87-MG cells. A: The relative mRNA levels of miR221/222 in cells treated with AsmiR221/222. B: The protein level of Cx43 in U87-MG cells when treated with As-miR221/222. C: The binding sites of miR-221/222 and Cx43. D: The result of dual luciferase reporter assay. *p<0.01.
